Highlights

  • van den Boorn, J. G., Jakobs, C., Hagen, C., Renn, M., Luiten, R. M., Melief, C. J., Tuting, T., Garbi, N., Hartmann, G.* and Hornung, V*. Inflammasome-Dependent Induction of Adaptive NK Cell Memory Immunity, 2016; 44: 1406-21

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  • Roers, A., B. Hiller and V. Hornung. Recognition of Endogenous Nucleic Acids by the Innate Immune System Immunity, 2016; 44: 739-54

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  • Gaidt, M. M., T. S. Ebert, D. Chauhan, T. Schmidt, J. L. Schmid-Burgk, F. Rapino, A. A. Robertson, M. A. Cooper, T. Graf and V. Hornung. Human Monocytes Engage an Alternative Inflammasome Pathway Immunity, 2016; 44(4):833-46

    Link

  • Schmid-Burgk, J. L. and V. Hornung. BrowserGenome.org: web-based RNA-seq data analysis and visualization Nat Methods, 2015; 12: 1001

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  • Hornung, V., R. Hartmann, A. Ablasser and K. P. Hopfner. OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids Nat Rev Immunol, 2014; 14: 521-8

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  • Kim, S., J. Becker, M. Bechheim, V. Kaiser, M. Noursadeghi, N. Fricker, E. Beier, S. Klaschik, P. Boor, T. Hess, A. Hofmann, S. Holdenrieder, J. R. Wendland, H. Frohlich, G. Hartmann, M. M. Nothen, B. Muller-Myhsok, B. Putz*, V. Hornung* and J. Schumacher*. Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes Nat Commun, 2014; 5: 5236

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  • Ablasser, A., J. L. Schmid-Burgk, I. Hemmerling, G. L. Horvath, T. Schmidt, E. Latz and V. Hornung. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP Nature, 2013; 503: 530-534.

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  • Ablasser, A., M. Goldeck, T. Cavlar, T. Deimling, G. Witte, I. Rohl, K. P. Hopfner, J. Ludwig and V. Hornung. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING Nature, 2013; 498: 380-384.

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  • Bartok, E., F. Bauernfeind, M. G. Khaminets, C. Jakobs, B. Monks, K. A. Fitzgerald, E. Latz and V. Hornung. iGLuc: a luciferase-based inflammasome and protease activity reporter Nat Methods, 2013; 10: 147-154.

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  • Schmid-Burgk, J. L., T. Schmidt, V. Kaiser, K. Honing and V. Hornung. A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes Nat Biotechnol, 2013; 31: 76-81.

    Link

  • Duewell, P., H. Kono, K. J. Rayner, C. M. Sirois, G. Vladimer, F. G. Bauernfeind, G. S. Abela, L. Franchi, G. Nunez, M. Schnurr, T. Espevik, E. Lien, K. A. Fitzgerald, K. L. Rock, K. J. Moore, S. D. Wright, V. Hornung and E. Latz. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals Nature, 2010; 464: 1357-1361.

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  • Ablasser, A., F. Bauernfeind, G. Hartmann, E. Latz, K. A. Fitzgerald and V. Hornung. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate Nat Immunol, 2009; 10: 1065-1072.

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  • Hornung, V., A. Ablasser, M. Charrel-Dennis, F. Bauernfeind, G. Horvath, D. R. Caffrey, E. Latz and K. A. Fitzgerald. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC Nature, 2009; 458: 514-518.

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  • Hornung, V., F. Bauernfeind, A. Halle, E. O. Samstad, H. Kono, K. L. Rock, K. A. Fitzgerald and E. Latz. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization Nat Immunol, 2008; 9: 847-856.

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  • Hornung, V., J. Ellegast, S. Kim, K. Brzozka, A. Jung, H. Kato, H. Poeck, S. Akira, K. K. Conzelmann, M. Schlee, S. Endres and G. Hartmann. 5'-Triphosphate RNA is the ligand for RIG-I Science, 2006; 314: 994-997.

    Link

  • Hornung, V., M. Guenthner-Biller, C. Bourquin, A. Ablasser, M. Schlee, S. Uematsu, A. Noronha, M. Manoharan, S. Akira, A. de Fougerolles, S. Endres and G. Hartmann. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7 Nat Med, 2005; 11: 263-270.

    Link

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