Scientific Papers

  • 2017

  • Kim-Hellmuth, S., Bechheim, M., Putz, B., Mohammadi, P., Nedelec, Y., Giangreco, N., Becker, J., Kaiser, V., Fricker, N., Beier, E., Boor, P., Castel, S. E., Nothen, M. M., Barreiro, L. B., Pickrell, J. K., Muller-Myhsok, B., Lappalainen, T., Schumacher, J. and Hornung, V. Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations Nat Commun, 2017

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  • Schneider, C., Oellerich, T., Baldauf, H. M., Schwarz, S. M., Thomas, D., Flick, R., Bohnenberger, H., Kaderali, L., Stegmann, L., Cremer, A., Martin, M., Lohmeyer, J., Michaelis, M., Hornung, V., Schliemann, C., Berdel, W. E., Hartmann, W., Wardelmann, E., Comoglio, F., Hansmann, M. L., Yakunin, A. F., Geisslinger, G., Strobel, P., Ferreiros, N., Serve, H., Keppler, O. T. and Cinatl, J., Jr. Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia Nat Med, 2017

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  • Engel, C., Brugmann, G., Lambing, S., Muhlenbeck, L. H., Marx, S., Hagen, C., Horvath, D., Goldeck, M., Ludwig, J., Herzner, A. M., Drijfhout, J. W., Wenzel, D., Coch, C., Tuting, T., Schlee, M., Hornung, V., Hartmann, G. and Van den Boorn, J. G. RIG-I resists hypoxia-induced immunosuppression and dedifferentiation Cancer Immunol Res, 2017

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  • Karlstetter, M., J. Kopatz, A. Aslanidis, A. Shahraz, A. Caramoy, B. Linnartz-Gerlach, Y. Lin, A. Luckoff, S. Fauser, K. Duker, J. Claude, Y. Wang, J. Ackermann, T. Schmidt, V. Hornung, C. Skerka, T. Langmann and H. Neumann. Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina EMBO Mol Med, 2017; 9: 154-166

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  • Mankan, A. K., M. Muller, G. Witte and V. Hornung. Cyclic Dinucleotides in the Scope of the Mammalian Immune System Handb Exp Pharmacol, 2017

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  • 2016

  • Schneider, C., T. Oellerich, H. M. Baldauf, S. M. Schwarz, D. Thomas, R. Flick, H. Bohnenberger, L. Kaderali, L. Stegmann, A. Cremer, M. Martin, J. Lohmeyer, M. Michaelis, V. Hornung, C. Schliemann, W. E. Berdel, W. Hartmann, E. Wardelmann, F. Comoglio, M. L. Hansmann, A. F. Yakunin, G. Geisslinger, P. Strobel, N. Ferreiros, H. Serve, O. T. Keppler and J. Cinatl, Jr. SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia Nat Med, 2016;

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  • Czogalla, K. J., A. Biswas, K. Honing, V. Hornung, K. Liphardt, M. Watzka and J. Oldenburg. Warfarin and vitamin K compete for binding to Phe55 in human VKOR Nat Struct Mol Biol, 2016;

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  • Gaidt, M. M. and V. Hornung. Alternative inflammasome activation enables IL-1beta release from living cells Curr Opin Immunol, 2016; 44: 7-13

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  • Vercruysse, T., J. De Bie, J. Neggers, M. Jacquemyn, E. Vanstreels, J. L. Schmid-Burgk, V. Hornung, E. Baloglu, Y. Landesman, W. Senapedis, S. Shacham, A. Dagklis, J. Cools and D. Daelemans. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia Clin Cancer Res, 2016;

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  • Gaidt, M. M. and V. Hornung. Pore formation by GSDMD is the effector mechanism of pyroptosis Embo j, 2016; 35: 2167-2169

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  • Baum, R., S. Sharma, J. M. Organ, C. Jakobs, V. Hornung, D. B. Burr, A. Marshak-Rothstein, K. A. Fitzgerald and E. M. Gravallese. STING regulates abnormal bone formation induced by deficiency of DNase II Arthritis Rheumatol, 2016;

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  • Vercruysse, T., J. De Bie, J. Neggers, M. Jacquemyn, E. Vanstreels, J. L. Schmid-Burgk, V. Hornung, E. Baloglu, Y. Landesman, W. Senapedis, S. Shacham, A. Dagklis, J. Cools and D. Daelemans. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia Clin Cancer Res, 2016

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  • Xu, S., A. Ducroux, A. Ponnurangam, G. Vieyres, S. Franz, M. Musken, T. Zillinger, A. Malassa, E. Ewald, V. Hornung, W. Barchet, S. Haussler, T. Pietschmann and C. Goffinet. cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites Cell Host Microbe, 2016; 20: 443-457

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  • Bauernfeind, F., S. Niepmann, P. A. Knolle and V. Hornung. Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances J Immunol, 2016

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  • Gaidt, M. M. and V. Hornung. Pore formation by GSDMD is the effector mechanism of pyroptosis Embo j, 2016; 35: 2167-2169

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  • Schmid-Burgk, J. L., K. Honing, T. S. Ebert and V. Hornung. CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism Nat Commun, 2016; 7: 12338

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  • Andrade, W. A., A. Firon, T. Schmidt, V. Hornung, K. A. Fitzgerald, E. A. Kurt-Jones, P. Trieu-Cuot, D. T. Golenbock and P. A. Kaminski. Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production Cell Host Microbe, 2016; 20: 49-59

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  • van den Boorn, J. G., C. Jakobs, C. Hagen, M. Renn, R. M. Luiten, C. J. Melief, T. Tuting, N. Garbi, G. Hartmann and V. Hornung. Inflammasome-Dependent Induction of Adaptive NK Cell Memory Immunity, 2016;

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  • Andrade, W. A., S. Agarwal, S. Mo, S. A. Shaffer, J. P. Dillard, T. Schmidt, V. Hornung, K. A. Fitzgerald, E. A. Kurt-Jones and D. T. Golenbock. Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4 Cell Rep, 2016; 15: 2438-48

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  • Ludwig-Portugall, I., E. Bartok, E. Dhana, B. D. Evers, M. J. Primiano, J. P. Hall, B. S. Franklin, P. A. Knolle, V. Hornung, G. Hartmann, P. Boor, E. Latz and C. Kurts. An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice Kidney Int, 2016;

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  • Bartok, E., M. Kampes and V. Hornung. Measuring IL-1beta Processing by Bioluminescence Sensors II: The iGLuc System Methods Mol Biol, 2016; 1417: 97-113

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  • Paijo, J., M. Doring, J. Spanier, E. Grabski, M. Nooruzzaman, T. Schmidt, G. Witte, M. Messerle, V. Hornung, V. Kaever and U. Kalinke. cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells PLoS Pathog, 2016; 12: e1005546

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  • Roers, A., B. Hiller and V. Hornung. Recognition of Endogenous Nucleic Acids by the Innate Immune System Immunity, 2016; 44: 739-54

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  • Kainulainen, M., S. Lau, C. E. Samuel, V. Hornung and F. Weber. NSs virulence factor of Rift Valley fever virus engages the F-box proteins FBXW11 and beta-TRCP1 to degrade the antiviral protein kinase PKR J Virol, 2016;

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  • Bode, C., M. Fox, P. Tewary, A. Steinhagen, R. K. Ellerkmann, D. Klinman, G. Baumgarten, V. Hornung and F. Steinhagen. Human plasmacytoid dentritic cells elicit a Type I Interferon response by sensing DNA via the cGAS-STING signaling pathway Eur J Immunol. 2016;

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  • Pepin, G., J. Ferrand, K. Honing, W. S. Jayasekara, J. E. Cain, M. A. Behlke, D. J. Gough, G. W. BR, V. Hornung and M. P. Gantier. Cre-dependent DNA recombination activates a STING-dependent innate immune response Nucleic Acids Res. 2016;

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  • Gaidt, M. M., T. S. Ebert, D. Chauhan, T. Schmidt, J. L. Schmid-Burgk, F. Rapino, A. A. Robertson, M. A. Cooper, T. Graf and V. Hornung. Human Monocytes Engage an Alternative Inflammasome Pathway Immunity, 2016;

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  • Cuevas, R. A., A. Ghosh, C. Wallerath, V. Hornung, C. B. Coyne and S. N. Sarkar. MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction J Immunol, 2016;

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  • Krapp, C., D. Hotter, A. Gawanbacht, P. J. McLaren, S. F. Kluge, C. M. Sturzel, K. Mack, E. Reith, S. Engelhart, A. Ciuffi, V. Hornung, D. Sauter, A. Telenti and F. Kirchhoff. Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity Cell Host Microbe, 2016;

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  • Holm, C. K., S. H. Rahbek, H. H. Gad, R. O. Bak, M. R. Jakobsen, Z. Jiang, A. L. Hansen, S. K. Jensen, C. Sun, M. K. Thomsen, A. Laustsen, C. G. Nielsen, K. Severinsen, Y. Xiong, D. L. Burdette, V. Hornung, R. J. Lebbink, M. Duch, K. A. Fitzgerald, S. Bahrami, J. G. Mikkelsen, R. Hartmann and S. R. Paludan. Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses Nat Commun, 2016; 7: 10680

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  • Sun, J., N. Li, K. S. Oh, B. Dutta, S. J. Vayttaden, B. Lin, T. S. Ebert, D. De Nardo, J. Davis, R. Bagirzadeh, N. W. Lounsbury, C. Pasare, E. Latz, V. Hornung and I. D. Fraser. Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use Sci Signal, 2016; 9: ra3

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  • Schmid-Burgk, J. L., D. Chauhan, T. Schmidt, T. S. Ebert, J. Reinhardt, E. Endl and V. Hornung. A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation J Biol Chem, 2016; 291: 103-109.

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  • Schmidt, T., J. L. Schmid-Burgk, T. S. Ebert, M. M. Gaidt and V. Hornung. Designer Nuclease-Mediated Generation of Knockout THP1 Cells Methods Mol Biol, 2016; 1338: 261-272.

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  • 2015

  • Wittmann, S., R. Behrendt, K. Eissmann, B. Volkmann, D. Thomas, T. Ebert, A. Cribier, M. Benkirane, V. Hornung, N. F. Bouzas and T. Gramberg. Phosphorylation of murine SAMHD1 regulates its antiretroviral activity Retrovirology, 2015; 12: 103.

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  • Lassig, C., S. Matheisl, K. M. Sparrer, C. C. de Oliveira Mann, M. Moldt, J. R. Patel, M. Goldeck, G. Hartmann, A. Garcia-Sastre, V. Hornung, K. K. Conzelmann, R. Beckmann and K. P. Hopfner. ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA Elife, 2015; 4:

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  • Kruger, A., M. Oldenburg, C. Chebrolu, D. Beisser, J. Kolter, A. M. Sigmund, J. Steinmann, S. Schafer, H. Hochrein, S. Rahmann, H. Wagner, P. Henneke, V. Hornung, J. Buer and C. J. Kirschning. Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA EMBO Rep, 2015; 16: 1656-1663.

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  • Riesenberg, S., A. Groetchen, R. Siddaway, T. Bald, J. Reinhardt, D. Smorra, J. Kohlmeyer, M. Renn, B. Phung, P. Aymans, T. Schmidt, V. Hornung, I. Davidson, C. R. Goding, G. Jonsson, J. Landsberg, T. Tuting and M. Holzel. MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment Nat Commun, 2015; 6: 8755.

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  • Schmid-Burgk, J. L. and V. Hornung. BrowserGenome.org: web-based RNA-seq data analysis and visualization Nat Methods, 2015; 12: 1001.

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  • Schmidt, T., J. L. Schmid-Burgk and V. Hornung. Synthesis of an arrayed sgRNA library targeting the human genome Sci Rep, 2015; 5: 14987.

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  • Anz, D., M. Rapp, S. Eiber, V. H. Koelzer, R. Thaler, S. Haubner, M. Knott, S. Nagel, M. Golic, G. M. Wiedemann, F. Bauernfeind, C. Wurzenberger, V. Hornung, C. Scholz, D. Mayr, S. Rothenfusser, S. Endres and C. Bourquin. Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression Cancer Res, 2015; 75: 4483-4493.

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  • Herzner, A. M., C. A. Hagmann, M. Goldeck, S. Wolter, K. Kubler, S. Wittmann, T. Gramberg, L. Andreeva, K. P. Hopfner, C. Mertens, T. Zillinger, T. Jin, T. S. Xiao, E. Bartok, C. Coch, D. Ackermann, V. Hornung, J. Ludwig, W. Barchet, G. Hartmann and M. Schlee. Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA Nat Immunol, 2015; 16: 1025-1033.

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  • Hiller, B. and V. Hornung. STING Signaling the enERGIC Way Cell Host Microbe, 2015; 18: 137-139.

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  • Andersen, L. L., N. Mork, L. S. Reinert, E. Kofod-Olsen, R. Narita, S. E. Jorgensen, K. A. Skipper, K. Honing, H. H. Gad, L. Ostergaard, T. F. Orntoft, V. Hornung, S. R. Paludan, J. G. Mikkelsen, T. Fujita, M. Christiansen, R. Hartmann and T. H. Mogensen. Functional IRF3 deficiency in a patient with herpes simplex encephalitis J Exp Med, 2015; 212: 1371-1379.

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  • Schuberth-Wagner, C., J. Ludwig, A. K. Bruder, A. M. Herzner, T. Zillinger, M. Goldeck, T. Schmidt, J. L. Schmid-Burgk, R. Kerber, S. Wolter, J. P. Stumpel, A. Roth, E. Bartok, C. Drosten, C. Coch, V. Hornung, W. Barchet, B. M. Kummerer, G. Hartmann and M. Schlee. A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA Immunity, 2015; 43: 41-51.

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  • Schmid-Burgk, J. L., M. M. Gaidt, T. Schmidt, T. S. Ebert, E. Bartok and V. Hornung. Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells Eur J Immunol, 2015; 45: 2911-2917.

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  • Sester, D. P., V. Sagulenko, S. J. Thygesen, J. A. Cridland, Y. S. Loi, S. O. Cridland, S. L. Masters, U. Genske, V. Hornung, C. E. Andoniou, M. J. Sweet, M. A. Degli-Esposti, K. Schroder and K. J. Stacey. Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice J Immunol, 2015; 195: 1233-1241.

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  • Jakobs, C., S. Perner and V. Hornung. AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis PLoS One, 2015; 10: e0131702.

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  • Wassermann, R., M. F. Gulen, C. Sala, S. G. Perin, Y. Lou, J. Rybniker, J. L. Schmid-Burgk, T. Schmidt, V. Hornung, S. T. Cole and A. Ablasser. Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1 Cell Host Microbe, 2015; 17: 799-810.

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  • Ibsen, M. S., H. H. Gad, L. L. Andersen, V. Hornung, I. Julkunen, S. N. Sarkar and R. Hartmann. Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling Nucleic Acids Res, 2015; 43: 5236-5248.

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  • Yao, H., M. Dittmann, A. Peisley, H. H. Hoffmann, R. H. Gilmore, T. Schmidt, J. L. Schmid-Burgk, V. Hornung, C. M. Rice and S. Hur. ATP-dependent effector-like functions of RIG-I-like receptors Mol Cell, 2015; 58: 541-548.

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  • Barrangou, R., A. Birmingham, S. Wiemann, R. L. Beijersbergen, V. Hornung and A. Smith. Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference Nucleic Acids Res, 2015; 43: 3407-3419.

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  • Mankan, A. K. and V. Hornung. Sox2 as a servant of two masters Nat Immunol, 2015; 16: 335-336.

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  • Weber, M., H. Sediri, U. Felgenhauer, I. Binzen, S. Banfer, R. Jacob, L. Brunotte, A. Garcia-Sastre, J. L. Schmid-Burgk, T. Schmidt, V. Hornung, G. Kochs, M. Schwemmle, H. D. Klenk and F. Weber. Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I Cell Host Microbe, 2015; 17: 309-319.

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  • Yakut, E., C. Jakobs, A. Peric, G. Michel, N. Baal, G. Bein, B. Brune, V. Hornung and H. Hackstein. Extracorporeal photopheresis promotes IL-1beta production J Immunol, 2015; 194: 2569-2577.

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  • Anggakusuma, A. Frentzen, E. Gurlevik, Q. Yuan, E. Steinmann, M. Ott, P. Staeheli, J. Schmid-Burgk, T. Schmidt, V. Hornung, F. Kuehnel and T. Pietschmann. Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons J Virol, 2015; 89: 3833-3845.

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  • 2014

  • Hornung, V. SnapShot: Nucleic acid immune sensors, part 2 Immunity, 2014; 41: 1066-1066 e1061.

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  • Hornung, V. SnapShot: nucleic acid immune sensors, part 1 Immunity, 2014; 41: 868, 868 e861.

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  • Mankan, A. K., T. Schmidt, D. Chauhan, M. Goldeck, K. Honing, M. Gaidt, A. V. Kubarenko, L. Andreeva, K. P. Hopfner and V. Hornung. Cytosolic RNA:DNA hybrids activate the cGAS-STING axis EMBO J, 2014; 33: 2937-2946.

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  • Schmid-Burgk, J. L., T. Schmidt and V. Hornung. Ligation-independent cloning (LIC) assembly of TALEN genes Methods Mol Biol, 2015; 1239: 161-169.

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  • Kim, S., J. Becker, M. Bechheim, V. Kaiser, M. Noursadeghi, N. Fricker, E. Beier, S. Klaschik, P. Boor, T. Hess, A. Hofmann, S. Holdenrieder, J. R. Wendland, H. Frohlich, G. Hartmann, M. M. Nothen, B. Muller-Myhsok, B. Putz, V. Hornung and J. Schumacher. Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes Nat Commun, 2014; 5: 5236.

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  • Pelka, K., K. Phulphagar, J. Zimmermann, R. Stahl, J. L. Schmid-Burgk, T. Schmidt, J. H. Spille, L. I. Labzin, S. Agrawal, E. R. Kandimalla, J. L. Casanova, V. Hornung, A. Marshak-Rothstein, S. Honing and E. Latz. Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms J Immunol, 2014; 193: 3257-3261.

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  • Schmid-Burgk, J. L., T. Schmidt, M. M. Gaidt, K. Pelka, E. Latz, T. S. Ebert and V. Hornung. OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines Genome Res, 2014; 24: 1719-1723.

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  • Hornung, V., R. Hartmann, A. Ablasser and K. P. Hopfner. OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids Nat Rev Immunol, 2014; 14: 521-528.

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  • Goldeck, M., M. Schlee, G. Hartmann and V. Hornung. Enzymatic synthesis and purification of a defined RIG-I ligand Methods Mol Biol, 2014; 1169: 15-25.

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  • Zhu, J., Y. Zhang, A. Ghosh, R. A. Cuevas, A. Forero, J. Dhar, M. S. Ibsen, J. L. Schmid-Burgk, T. Schmidt, M. K. Ganapathiraju, T. Fujita, R. Hartmann, S. Barik, V. Hornung, C. B. Coyne and S. N. Sarkar. Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor Immunity, 2014; 40: 936-948.

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  • Ablasser, A., I. Hemmerling, J. L. Schmid-Burgk, R. Behrendt, A. Roers and V. Hornung. TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner J Immunol, 2014; 192: 5993-5997.

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  • Kim, S., V. Kaiser, E. Beier, M. Bechheim, M. Guenthner-Biller, A. Ablasser, M. Berger, S. Endres, G. Hartmann and V. Hornung. Self-priming determines high type I IFN production by plasmacytoid dendritic cells Eur J Immunol, 2014; 44: 807-818.

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  • 2013

  • Ablasser, A., J. L. Schmid-Burgk, I. Hemmerling, G. L. Horvath, T. Schmidt, E. Latz and V. Hornung. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP Nature, 2013; 503: 530-534.

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  • Stoffels, B., K. J. Hupa, S. A. Snoek, S. van Bree, K. Stein, T. Schwandt, T. O. Vilz, M. Lysson, C. V. Veer, M. P. Kummer, V. Hornung, J. C. Kalff, W. J. de Jonge and S. Wehner. Postoperative ileus involves interleukin-1 receptor signaling in enteric glia Gastroenterology, 2014; 146: 176-187 e171.

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  • Jakobs, C., E. Bartok, A. Kubarenko, F. Bauernfeind and V. Hornung. Immunoblotting for active caspase-1 Methods Mol Biol, 2013; 1040: 103-115.

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  • Yin, Q., D. P. Sester, Y. Tian, Y. S. Hsiao, A. Lu, J. A. Cridland, V. Sagulenko, S. J. Thygesen, D. Choubey, V. Hornung, T. Walz, K. J. Stacey and H. Wu. Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation Cell Rep, 2013; 4: 327-339.

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  • Civril, F., T. Deimling, C. C. de Oliveira Mann, A. Ablasser, M. Moldt, G. Witte, V. Hornung and K. P. Hopfner. Structural mechanism of cytosolic DNA sensing by cGAS Nature, 2013; 498: 332-337.

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  • Ablasser, A., M. Goldeck, T. Cavlar, T. Deimling, G. Witte, I. Rohl, K. P. Hopfner, J. Ludwig and V. Hornung. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING Nature, 2013; 498: 380-384.

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  • Bauernfeind, F. and V. Hornung. Of inflammasomes and pathogens--sensing of microbes by the inflammasome EMBO Mol Med, 2013; 5: 814-826.

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  • Hagmann, C. A., A. M. Herzner, Z. Abdullah, T. Zillinger, C. Jakobs, C. Schuberth, C. Coch, P. G. Higgins, H. Wisplinghoff, W. Barchet, V. Hornung, G. Hartmann and M. Schlee. RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells PLoS One, 2013; 8: e62872.

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  • Cavlar, T., T. Deimling, A. Ablasser, K. P. Hopfner and V. Hornung. Species-specific detection of the antiviral small-molecule compound CMA by STING EMBO J, 2013; 32: 1440-1450.

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  • Ablasser, A., C. Hertrich, R. Wassermann and V. Hornung. Nucleic acid driven sterile inflammation Clin Immunol, 2013; 147: 207-215.

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  • Ablasser, A. and V. Hornung. DNA sensing unchained Cell Res, 2013; 23: 585-587.

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  • Bartok, E., F. Bauernfeind, M. G. Khaminets, C. Jakobs, B. Monks, K. A. Fitzgerald, E. Latz and V. Hornung. iGLuc: a luciferase-based inflammasome and protease activity reporter Nat Methods, 2013; 10: 147-154.

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  • Schmid-Burgk, J. L., T. Schmidt, V. Kaiser, K. Honing and V. Hornung. A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes Nat Biotechnol, 2013; 31: 76-81.

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  • 2012

  • Mankan, A. K. and V. Hornung. Retroviral danger from within: TLR7 is in control Immunity, 2012; 37: 763-766.

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  • Bauernfeind, F., A. Rieger, F. A. Schildberg, P. A. Knolle, J. L. Schmid-Burgk and V. Hornung. NLRP3 inflammasome activity is negatively controlled by miR-223 J Immunol, 2012; 189: 4175-4181.

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  • Jin, T., A. Perry, J. Jiang, P. Smith, J. A. Curry, L. Unterholzner, Z. Jiang, G. Horvath, V. A. Rathinam, R. W. Johnstone, V. Hornung, E. Latz, A. G. Bowie, K. A. Fitzgerald and T. S. Xiao. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor Immunity, 2012; 36: 561-571.

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  • Cavlar, T., A. Ablasser and V. Hornung. Induction of type I IFNs by intracellular DNA-sensing pathways Immunol Cell Biol, 2012; 90: 474-482.

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  • Mankan, A. K., A. Kubarenko and V. Hornung. Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation Clin Exp Immunol, 2012; 167: 369-381.

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  • Mankan, A. K., T. Dau, D. Jenne and V. Hornung. The NLRP3/ASC/Caspase-1 axis regulates IL-1beta processing in neutrophils Eur J Immunol, 2012; 42: 710-715.

    Link

  • 2011

  • Schlaweck, S., S. Zimmer, R. Struck, E. Bartok, N. Werner, F. Bauernfeind, E. Latz, G. Nickenig, V. Hornung and A. Ghanem. Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair Biochem Biophys Res Commun, 2011; 411: 627-631.

    Link

  • Ablasser, A. and V. Hornung. Where, in antiviral defense, does IFIT1 fit? Nat Immunol, 2011; 12: 588-590.

    Link

  • Bauernfeind, F., E. Bartok, A. Rieger, L. Franchi, G. Nunez and V. Hornung. Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome J Immunol, 2011; 187: 613-617.

    Link

  • Dombrowski, Y., M. Peric, S. Koglin, C. Kammerbauer, C. Goss, D. Anz, M. Simanski, R. Glaser, J. Harder, V. Hornung, R. L. Gallo, T. Ruzicka, R. Besch and J. Schauber. Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions Sci Transl Med, 2011; 3: 82ra38.

    Link

  • Bauernfeind, F., A. Ablasser, E. Bartok, S. Kim, J. Schmid-Burgk, T. Cavlar and V. Hornung. Inflammasomes: current understanding and open questions Cell Mol Life Sci, 2011; 68: 765-783.

    Link

  • Winter, M., H. D. Beer, V. Hornung, U. Kramer, R. P. Schins and I. Forster. Activation of the inflammasome by amorphous silica and TiO2 nanoparticles in murine dendritic cells Nanotoxicology, 2011; 5: 326-340.

    Link

  • 2010

  • Bauernfeind, F., A. Ablasser, S. Kim, E. Bartok and V. Hornung. An unexpected role for RNA in the recognition of DNA by the innate immune system RNA Biol, 2010; 7: 151-157.

    Link

  • Duewell, P., H. Kono, K. J. Rayner, C. M. Sirois, G. Vladimer, F. G. Bauernfeind, G. S. Abela, L. Franchi, G. Nunez, M. Schnurr, T. Espevik, E. Lien, K. A. Fitzgerald, K. L. Rock, K. J. Moore, S. D. Wright, V. Hornung and E. Latz. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals Nature, 2010; 464: 1357-1361.

    Link

  • Rathinam, V. A., Z. Jiang, S. N. Waggoner, S. Sharma, L. E. Cole, L. Waggoner, S. K. Vanaja, B. G. Monks, S. Ganesan, E. Latz, V. Hornung, S. N. Vogel, E. Szomolanyi-Tsuda and K. A. Fitzgerald. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses Nat Immunol, 2010; 11: 395-402.

    Link

  • Kim, S., F. Bauernfeind, A. Ablasser, G. Hartmann, K. A. Fitzgerald, E. Latz and V. Hornung. Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome Eur J Immunol, 2010; 40: 1545-1551.

    Link

  • Hornung, V. and E. Latz. Critical functions of priming and lysosomal damage for NLRP3 activation Eur J Immunol, 2010; 40: 620-623.

    Link

  • Hornung, V. and E. Latz. Intracellular DNA recognition Nat Rev Immunol, 2010; 10: 123-130.

    Link

  • Anz, D., V. H. Koelzer, S. Moder, R. Thaler, T. Schwerd, K. Lahl, T. Sparwasser, R. Besch, H. Poeck, V. Hornung, G. Hartmann, S. Rothenfusser, C. Bourquin and S. Endres. Immunostimulatory RNA blocks suppression by regulatory T cells J Immunol, 2010; 184: 939-946.

    Link

  • Poeck, H., M. Bscheider, O. Gross, K. Finger, S. Roth, M. Rebsamen, N. Hannesschlager, M. Schlee, S. Rothenfusser, W. Barchet, H. Kato, S. Akira, S. Inoue, S. Endres, C. Peschel, G. Hartmann, V. Hornung and J. Ruland. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production Nat Immunol, 2010; 11: 63-69.

    Link

  • 2009

  • Bourquin, C., L. Schmidt, A. L. Lanz, B. Storch, C. Wurzenberger, D. Anz, N. Sandholzer, R. Mocikat, M. Berger, H. Poeck, G. Hartmann, V. Hornung and S. Endres. Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7 J Immunol, 2009; 183: 6078-6086.

    Link

  • Bauernfeind, F. and V. Hornung. TLR2 joins the interferon gang Nat Immunol, 2009; 10: 1139-1141.

    Link

  • Besch, R., H. Poeck, T. Hohenauer, D. Senft, G. Hacker, C. Berking, V. Hornung, S. Endres, T. Ruzicka, S. Rothenfusser and G. Hartmann. Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells J Clin Invest, 2009; 119: 2399-2411.

    Link

  • Ablasser, A., F. Bauernfeind, G. Hartmann, E. Latz, K. A. Fitzgerald and V. Hornung. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate Nat Immunol, 2009; 10: 1065-1072.

    Link

  • Schlee, M., A. Roth, V. Hornung, C. A. Hagmann, V. Wimmenauer, W. Barchet, C. Coch, M. Janke, A. Mihailovic, G. Wardle, S. Juranek, H. Kato, T. Kawai, H. Poeck, K. A. Fitzgerald, O. Takeuchi, S. Akira, T. Tuschl, E. Latz, J. Ludwig and G. Hartmann. Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus Immunity, 2009; 31: 25-34.

    Link

  • Bauernfeind, F. G., G. Horvath, A. Stutz, E. S. Alnemri, K. MacDonald, D. Speert, T. Fernandes-Alnemri, J. Wu, B. G. Monks, K. A. Fitzgerald, V. Hornung and E. Latz. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression J Immunol, 2009; 183: 787-791.

    Link

  • Ablasser, A., H. Poeck, D. Anz, M. Berger, M. Schlee, S. Kim, C. Bourquin, N. Goutagny, Z. Jiang, K. A. Fitzgerald, S. Rothenfusser, S. Endres, G. Hartmann and V. Hornung. Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes J Immunol, 2009; 182: 6824-6833.

    Link

  • Berger, M., A. Ablasser, S. Kim, I. Bekeredjian-Ding, T. Giese, S. Endres, V. Hornung and G. Hartmann. TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA J Immunother, 2009; 32: 262-271.

    Link

  • Hornung, V., A. Ablasser, M. Charrel-Dennis, F. Bauernfeind, G. Horvath, D. R. Caffrey, E. Latz and K. A. Fitzgerald. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC Nature, 2009; 458: 514-518.

    Link

  • Lichtnekert, J., V. Vielhauer, D. Zecher, O. P. Kulkarni, S. Clauss, S. Segerer, V. Hornung, T. N. Mayadas, B. Beutler, S. Akira and H. J. Anders. Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif Am J Physiol Renal Physiol, 2009; 296: F867-874.

    Link

  • 2008

  • Allam, R., R. D. Pawar, O. P. Kulkarni, V. Hornung, G. Hartmann, S. Segerer, S. Akira, S. Endres and H. J. Anders. Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses Eur J Immunol, 2008; 38: 3487-3498.

    Link

  • Poeck, H., R. Besch, C. Maihoefer, M. Renn, D. Tormo, S. S. Morskaya, S. Kirschnek, E. Gaffal, J. Landsberg, J. Hellmuth, A. Schmidt, D. Anz, M. Bscheider, T. Schwerd, C. Berking, C. Bourquin, U. Kalinke, E. Kremmer, H. Kato, S. Akira, R. Meyers, G. Hacker, M. Neuenhahn, D. Busch, J. Ruland, S. Rothenfusser, M. Prinz, V. Hornung, S. Endres, T. Tuting and G. Hartmann. 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma Nat Med, 2008; 14: 1256-1263.

    Link

  • Geeraedts, F., N. Goutagny, V. Hornung, M. Severa, A. de Haan, J. Pool, J. Wilschut, K. A. Fitzgerald and A. Huckriede. Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling PLoS Pathog, 2008; 4: e1000138.

    Link

  • Hornung, V., F. Bauernfeind, A. Halle, E. O. Samstad, H. Kono, K. L. Rock, K. A. Fitzgerald and E. Latz. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization Nat Immunol, 2008; 9: 847-856.

    Link

  • Halle, A., V. Hornung, G. C. Petzold, C. R. Stewart, B. G. Monks, T. Reinheckel, K. A. Fitzgerald, E. Latz, K. J. Moore and D. T. Golenbock. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta Nat Immunol, 2008; 9: 857-865.

    Link

  • Hornung, V., W. Barchet, M. Schlee and G. Hartmann. RNA recognition via TLR7 and TLR8 Handb Exp Pharmacol, 2008; 71-86.

    Link

  • 2007

  • Schlee, M., W. Barchet, V. Hornung and G. Hartmann. Beyond double-stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids Curr Top Microbiol Immunol, 2007; 316: 207-230.

  • Landgraf, P., M. Rusu, R. Sheridan, A. Sewer, N. Iovino, A. Aravin, S. Pfeffer, A. Rice, A. O. Kamphorst, M. Landthaler, C. Lin, N. D. Socci, L. Hermida, V. Fulci, S. Chiaretti, R. Foa, J. Schliwka, U. Fuchs, A. Novosel, R. U. Muller, B. Schermer, U. Bissels, J. Inman, Q. Phan, M. Chien, D. B. Weir, R. Choksi, G. De Vita, D. Frezzetti, H. I. Trompeter, V. Hornung, G. Teng, G. Hartmann, M. Palkovits, R. Di Lauro, P. Wernet, G. Macino, C. E. Rogler, J. W. Nagle, J. Ju, F. N. Papavasiliou, T. Benzing, P. Lichter, W. Tam, M. J. Brownstein, A. Bosio, A. Borkhardt, J. J. Russo, C. Sander, M. Zavolan and T. Tuschl. A mammalian microRNA expression atlas based on small RNA library sequencing Cell, 2007; 129: 1401-1414.

    Link

  • Bourquin, C., L. Schmidt, V. Hornung, C. Wurzenberger, D. Anz, N. Sandholzer, S. Schreiber, A. Voelkl, G. Hartmann and S. Endres. Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response Blood, 2007; 109: 2953-2960.

    Link

  • 2006

  • Hornung, V., J. Ellegast, S. Kim, K. Brzozka, A. Jung, H. Kato, H. Poeck, S. Akira, K. K. Conzelmann, M. Schlee, S. Endres and G. Hartmann. 5'-Triphosphate RNA is the ligand for RIG-I Science, 2006; 314: 994-997.

    Link

  • Schlee, M., V. Hornung and G. Hartmann. siRNA and isRNA: two edges of one sword Mol Ther, 2006; 14: 463-470.

    Link

  • Bekeredjian-Ding, I., S. I. Roth, S. Gilles, T. Giese, A. Ablasser, V. Hornung, S. Endres and G. Hartmann. T cell-independent, TLR-induced IL-12p70 production in primary human monocytes J Immunol, 2006; 176: 7438-7446

  • 2005

  • Edelmann, M., F. Gamarra, A. K. da Silva, V. Hornung, M. Castro, B. Passlick, R. M. Huber and A. Bergner. Cell cycle effects of radiation on human bronchial epithelium and lung carcinoma cells in monolayer cultures and a three-dimensional co-culture system Radiat Res, 2005; 164: 391-399.

  • Renner, E. D., I. Pawlita, F. Hoffmann, V. Hornung, D. Hartl, M. Albert, A. Jansson, S. Endres, G. Hartmann, B. H. Belohradsky and S. Rothenfusser. No indication for a defect in toll-like receptor signaling in patients with hyper-IgE syndrome J Clin Immunol, 2005; 25: 321-328.

    Link

  • Marschner, A., S. Rothenfusser, V. Hornung, D. Prell, A. Krug, M. Kerkmann, D. Wellisch, H. Poeck, A. Greinacher, T. Giese, S. Endres and G. Hartmann. CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells Eur J Immunol, 2005; 35: 2347-2357.

    Link

  • Schlender, J., V. Hornung, S. Finke, M. Gunthner-Biller, S. Marozin, K. Brzozka, S. Moghim, S. Endres, G. Hartmann and K. K. Conzelmann. Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus J Virol, 2005; 79: 5507-5515.

    Link

  • Bekeredjian-Ding, I. B., M. Wagner, V. Hornung, T. Giese, M. Schnurr, S. Endres and G. Hartmann. Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN J Immunol, 2005; 174: 4043-4050.

  • Hornung, V., M. Guenthner-Biller, C. Bourquin, A. Ablasser, M. Schlee, S. Uematsu, A. Noronha, M. Manoharan, S. Akira, A. de Fougerolles, S. Endres and G. Hartmann. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7 Nat Med, 2005; 11: 263-270.

    Link

  • Kerkmann, M., L. T. Costa, C. Richter, S. Rothenfusser, J. Battiany, V. Hornung, J. Johnson, S. Englert, T. Ketterer, W. Heckl, S. Thalhammer, S. Endres and G. Hartmann. Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells J Biol Chem, 2005; 280: 8086-8093.

    Link

  • 2004

  • Hornung, V., J. Schlender, M. Guenthner-Biller, S. Rothenfusser, S. Endres, K. K. Conzelmann and G. Hartmann. Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus J Immunol, 2004; 173: 5935-5943.

  • Poeck, H., M. Wagner, J. Battiany, S. Rothenfusser, D. Wellisch, V. Hornung, B. Jahrsdorfer, T. Giese, S. Endres and G. Hartmann. Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help Blood, 2004; 103: 3058-3064.

    Link

  • Rothenfusser, S., V. Hornung, M. Ayyoub, S. Britsch, A. Towarowski, A. Krug, A. Sarris, N. Lubenow, D. Speiser, S. Endres and G. Hartmann. CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro Blood, 2004; 103: 2162-2169.

    Link

  • 2003

  • Kerkmann, M., S. Rothenfusser, V. Hornung, A. Towarowski, M. Wagner, A. Sarris, T. Giese, S. Endres and G. Hartmann. Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells J Immunol, 2003; 170: 4465-4474.

  • 2002

  • Hornung, V., S. Rothenfusser, S. Britsch, A. Krug, B. Jahrsdorfer, T. Giese, S. Endres and G. Hartmann. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides J Immunol, 2002; 168: 4531-4537.

  • 2001

  • Rothenfusser, S., V. Hornung, A. Krug, A. Towarowski, A. M. Krieg, S. Endres and G. Hartmann. Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta Eur J Immunol, 2001; 31: 3525-3534.

  • Krug, A., A. Towarowski, S. Britsch, S. Rothenfusser, V. Hornung, R. Bals, T. Giese, H. Engelmann, S. Endres, A. M. Krieg and G. Hartmann. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12 Eur J Immunol, 2001; 31: 3026-3037.

    Link

  • Krug, A., S. Rothenfusser, V. Hornung, B. Jahrsdorfer, S. Blackwell, Z. K. Ballas, S. Endres, A. M. Krieg and G. Hartmann. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells Eur J Immunol, 2001; 31: 2154-2163.

    Link

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